Formulation and Evaluation of Clitoria ternatea Based Herbal Lotion for the Management of Psoriasis
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Abstract
Clitoria Ternatea Butter Pea Flower Hydroethanolic Extract Formulation of an Herbal Lotion with Anti-Inflammatory Properties Against Psoriasis is a chronic autoimmune inflammatory skin condition that affects about 2-3% of people around the world. It is characterized by thickened red, scaly patches on the body due to abnormal multiplication of skin cells and T-cell mediated inflammation. Current treatments such as corticosteroids, biologic agents and immunosuppressive drugs are often expensive and come with many side effects. This has led researchers to seek out safer alternatives. The purpose of this research was to formulate and evaluate a new herbal lotion containing hydroethanolic extract of Clitoria ternatea flower (also known as butterfly pea) along with other herbs such as aloevera gel, turmeric powder (containing curcumin), clove oil, acacia gum, xanthan gum, natural waxes and rose water. The lotion was created by mixing the various ingredients together in an oil/water emulsion and then evaluating its physical properties. Organoleptic characteristics were evaluated which include appearance, color, odor and texture; pH level was measured; homogenity was examined through visual inspection; viscosity (thickness) and spreadability were determined through viscometer measurements; washability and irratibility/sensitivity testing were performed on healthy volunteers; antimicrobial activity was tested against Malassezia spp. and Candida spp. using the disk diffusion test; lipoxygenase inhibiting activity (anti-inflammatory activity) was assayed in vitro; and finally MTT cytotoxic assays were conducted to determine if the lotion would inhibit keratinocyte proliferation. Results indicated that the pH levels of the lotion ranged from 5.5-6.5, it had good spreadability, a smooth texture and did not cause any skin irritation or sensitivity reactions in healthy volunteers. Furthermore, the lotion exhibited a strong zone of inhibition against all tested strains of bacteria.
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