Formulation and Evaluation of Herbal Anti-Acne Gel Containing Argemone Mexicana Leaf Extract
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Abstract
The Prickly Poppy (Argemone Mexicana L.) has been used for centuries due to its ethnomedicinal properties, being one of the most widespread plants in sub-tropical areas. It contains several bio-actives such as Isoquinolines Alkaloids (Sanguinarine, Berberine, Protopine and Chelerythrine), Flavonoids, Terpenes and Phenols, which are associated with Antimicrobial Activity, Anti-Oxidant Properties, Anti-Inflammatory Effects, Antimalarial Activities, and Anti-Cancerous Effects. The purpose of this research was to create and assess an Anti-Acne Gel that includes the Ethanolic Leaf Extract of A. Mexicana as the main Active Agent; Neem Oil and Aloe Vera Gel as Synergists, while utilizing Carbopol 940 as the Gelling Agent. Three different formulations (F1-F3) were developed at three different levels of concentration of the Plant Extract (0.1g, 0.2g and 0.3g respectively). Phyto-Chemical Screening confirmed the presence of alkaloids, tannins, flavonoids and glycosides in the extract. The evaluation parameters included Physical Appearance, pH Value, Viscosity, Spreadability, Extrudability, Homogenity, Drug Content, Washability, Skin Irritation and Antimicrobial Activity. F2 showed better than all the other formulations when it came to its Characteristics, these include a uniform appearance, pH value = 6.2 (compatible to skin), acceptable viscosity, good spreadability, high antimicrobial activity against Propionibacterium Acnes and Staphylococcus Aureus.
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