Formulation and Evaluation of Polyherbal Ayurvedic Anti-Inflammatory Lepa

Abstract

Inflammatory reactions protect damaged tissues during an injury or infection; chronic inflammatory responses produce signs such as pain, swelling, redness, and a variety of systemic diseases. Overuse of synthetic anti-inflammatory drugs has led to side effects that include gastrointestinal irritation, ulcers, kidney damage, and increased skin sensitivity. Therefore, the need for safer and less expensive alternatives such as herbal preparations has developed. This research study aimed at developing and evaluating a polyherbal Ayurvedic lepa containing Amla (Emblica officinalis), Turmeric (Curcuma longa), Vitex negundo, and Red Ochre (Geru) that would be both safe and effective. Each ingredient was chosen because it is important in traditional medicine and each component has well documented bioactive compounds. Specifically, curcumin in turmeric blocks the production of pro-inflammatory chemical messengers while Amla provides antioxidant activity and tissue repair; Vitex negundo produces analgesia and anti-inflammatory activity; and geru reduces heat in the affected area. After drying, grinding into powder form, sifting through fine mesh screens and mixing together in optimal proportions, the four ground powders were mixed with distilled water and then subjected to mechanical energy to create a smooth paste. The new product was tested for its quality characteristics including physical appearance, taste, odor, texture, pH level, ease of application, ability to remove after application, irritation to intact skin and stability. All results indicated excellent uniformity and mixtures had good physical properties that did not vary significantly over time when stored at room temperature.